Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

Author:

Scarfò Irene1ORCID,Pellegrino Elisa1ORCID,Mereu Elisabetta1,Kwee Ivo234,Agnelli Luca56ORCID,Bergaggio Elisa1,Garaffo Giulia1,Vitale Nicoletta1,Caputo Manuel1,Machiorlatti Rodolfo1,Circosta Paola1,Abate Francesco7,Barreca Antonella8,Novero Domenico8,Mathew Susan9,Rinaldi Andrea2,Tiacci Enrico10,Serra Sara1112,Deaglio Silvia1112,Neri Antonino56,Falini Brunangelo10,Rabadan Raul7,Bertoni Francesco213ORCID,Inghirami Giorgio19,Piva Roberto114ORCID,

Affiliation:

1. Department of Molecular Biotechnology and Health Sciences, Center for Experimental Research and Medical Studies, University of Turin, Turin, Italy;

2. Lymphoma and Genomics Research Program, Institute of Oncology Research, Bellinzona, Switzerland;

3. Dalle Molle Institute for Artificial Intelligence, Bellinzona, Switzerland;

4. Swiss Institute of Bioinformatics, Lausanne, Switzerland;

5. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy;

6. Hematology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Cà Granda–Ospedale Maggiore Policlinico, Milan, Italy;

7. Department of Biomedical Informatics, Columbia University College, New York, NY;

8. Città della Salute e della Scienza, Turin, Italy;

9. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY;

10. Institute of Hematology, University of Perugia, Ospedale S. Maria della Misericordia, S. Andrea delle Fratte, Perugia, Italy;

11. Department of Medical Sciences, University of Turin, Turin, Italy;

12. Human Genetics Foundation, Turin, Italy;

13. Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; and

14. Department of Pathology, New York University Cancer Center, New York University School of Medicine, New York, NY

Abstract

Key Points Endogenous intronic long terminal repeats promote the ectopic expression of truncated ERBB4 transcripts in 24% of ALK-negative ALCL. The expression of ERBB4-aberrant transcripts defines a new subclass of ALK-negative ALCL and may contribute to ALCL transformation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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