IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients

Author:

Pulsipher Michael A.1,Carlson Chris23,Langholz Bryan4,Wall Donna A.5,Schultz Kirk R.6,Bunin Nancy7,Kirsch Ilan3,Gastier-Foster Julie M.8910,Borowitz Michael11,Desmarais Cindy3,Williamson David3,Kalos Michael12,Grupp Stephan A.713

Affiliation:

1. Division of Hematology and Hematological Malignancies, Huntsman Cancer Institute/University of Utah School of Medicine, Primary Children’s Hospital, Salt Lake City, UT;

2. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Adaptive Biotechnologies, Seattle, WA;

4. Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA;

5. Manitoba Blood and Marrow Transplant Program, Winnipeg, MB, Canada;

6. Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, BC, Canada;

7. Division of Oncology, Children's Hospital of Philadelphia, and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

8. Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH;

9. Department of Pathology and

10. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH;

11. Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD;

12. Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and

13. Department of Pathology, Children's Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Abstract

Key Points IgH-V(D)J NGS-MRD detection pretransplant identifies a cohort at low risk for relapse, for which treatment modification could be considered. Positive NGS-MRD was highly predictive of relapse and survival as early as 30 days after HCT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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