Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21–mediated tumor suppressor Pdcd4 repression-Reference-Cited by-同舟云学术

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21–mediated tumor suppressor Pdcd4 repression

Published:2015-08-20 Issue:8 Volume:126 Page:993-1004
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Junker Fabian¹,Chabloz Antoine¹,Koch Ute¹,Radtke Freddy¹^ORCID

Affiliation:

1. Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Swiss Experimental Cancer Research Institute, Lausanne, Switzerland

Abstract

Key Points Dicer1-mediated miRNA biogenesis is essential for induction and maintenance of Notch1-driven T-ALL. miR-21 regulates survival of T-ALL, in part through the repression of the tumor suppressor gene Pdcd4.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/8/993/1391888/993.pdf

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