Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts-Reference-Cited by-同舟云学术

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

Published:2015-08-27 Issue:9 Volume:126 Page:1106-1117
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Paggetti Jerome¹,Haderk Franziska²,Seiffert Martina²,Janji Bassam¹,Distler Ute³,Ammerlaan Wim⁴,Kim Yeoun Jin³,Adam Julien⁵⁶,Lichter Peter²,Solary Eric⁶⁷,Berchem Guy¹⁸,Moussay Etienne¹

Affiliation:

1. Laboratory of Experimental Hemato-Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg;

2. Department for Molecular Genetics, German Cancer Research Center, Heidelberg, Germany;

3. Luxembourg Clinical Proteomics Center, Luxembourg Institute of Health, Luxembourg, Luxembourg;

4. Integrated BioBank of Luxembourg, Luxembourg, Luxembourg;

5. INSERM U981, Gustave Roussy, Villejuif, France;

6. Faculty of Medicine, University Paris-Sud, Le Kremlin-Bicêtre, France;

7. INSERM UMR1009, Gustave Roussy Villejuif, France; and

8. Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg

Abstract

Key Points CLL-derived exosomes are internalized by stromal cells, deliver functional microRNA and proteins, and activate key signaling pathways. Stromal cells exposed to CLL-derived exosomes demonstrate a CAF-like phenotype and secrete factors promoting CLL cell survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/9/1106/1391638/1106.pdf

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