Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3-Reference-Cited by-同舟云学术

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3

Published:2015-06-18 Issue:25 Volume:125 Page:3886-3895
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Goettel Jeremy A.¹²,Biswas Subhabrata²³,Lexmond Willem S.¹²,Yeste Ada²⁴,Passerini Laura⁵,Patel Bonny²⁴,Yang Siyoung⁶,Sun Jiusong²³,Ouahed Jodie¹²,Shouval Dror S.¹²,McCann Katelyn J.¹,Horwitz Bruce H.²⁷,Mathis Diane⁶,Milford Edgar L.²⁸,Notarangelo Luigi D.²⁹,Roncarolo Maria-Grazia⁵¹⁰,Fiebiger Edda¹²,Marasco Wayne A.²³,Bacchetta Rosa⁵,Quintana Francisco J.²⁴,Pai Sung-Yun²¹¹¹²,Klein Christoph¹³,Muise Aleixo M.¹⁴,Snapper Scott B.¹²¹⁵

Affiliation:

1. Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA;

2. Department of Medicine, Harvard Medical School, Boston, MA;

3. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA;

4. Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA;

5. Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, San Raffaele Telethon Institute for Gene Therapy, Milan, Italy;

6. Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA;

7. Department of Pathology, Brigham and Women’s Hospital, Boston, MA;

8. Renal Division and Tissue Typing Laboratory, Brigham and Women’s Hospital, Boston, MA;

9. Division of Immunology and The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA;

10. Vita-Salute San Raffaele University, Milan, Italy;

11. Division of Hematology-Oncology, Boston Children's Hospital, Boston, MA;

12. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA;

13. Department of Pediatrics, Dr von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany;

14. Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada; and

15. Division of Gastroenterology, Brigham and Women’s Hospital, Boston, MA

Abstract

Key Points Improved adaptive immune responses in humanized mice lacking murine MHC II and expressing human HLADR1. NOD.PrkdcscidIl2rγ−/−H2-Ab1−/− Tg(HLA-DR1) mice reconstituted with hematopoietic stem cells from an IPEX syndrome patient develop fatal autoimmunity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/25/3886/1386422/3886.pdf

Reference58 articles.

1. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412.;Suntharalingam;N Engl J Med,2006

2. Genomic responses in mouse models poorly mimic human inflammatory diseases.;Seok;Proc Natl Acad Sci USA,2013

3. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.;McKenzie;N Engl J Med,1995

4. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.;Xu;PLoS Med,2014

5. Humanized mice for immune system investigation: progress, promise and challenges.;Shultz;Nat Rev Immunol,2012

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cellular and molecular basis of proximal small intestine disorders;Nature Reviews Gastroenterology & Hepatology;2024-08-08

2. The oral–gut microbiome axis in health and disease;Nature Reviews Microbiology;2024-07-22

3. A novel FOXP3 knockout-humanized mouse model for pre-clinical safety and efficacy evaluation of Treg-like cell products;Molecular Therapy - Methods & Clinical Development;2023-12

4. Progress in building clinically relevant patient‐derived tumor xenograft models for cancer research;Animal Models and Experimental Medicine;2023-09-07

5. Humanized mouse models for immuno-oncology research;Nature Reviews Clinical Oncology;2023-01-12