Nocturnal oxygen saturation and painful sickle cell crises in children-Reference-Cited by-同舟云学术

Nocturnal oxygen saturation and painful sickle cell crises in children

Published:2003-02-01 Issue:3 Volume:101 Page:846-848
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Hargrave Darren R.¹,Wade Angie¹,Evans Jane P. M.¹,Hewes Deborah K. M.¹,Kirkham Fenella J.¹

Affiliation:

1. From the Department of Paediatric Epidemiology and Biostatistics and from the Neurosciences Unit, Institute of Child Health; Great Ormond Street Hospital; and Department of Haematology, University College Hospital; all of London, United Kingdom; and Paediatric Oncology Unit, The Royal Marsden Hospital, Sutton, United Kingdom.

Abstract

Abstract The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration, and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, laboratory, and sleep study data and frequency of painful crisis was investigated. Both univariate and multiple regression modeling showed that low nocturnal oxygen saturation was highly significantly associated with a higher rate of painful crisis in childhood (P < .0001). Screening and treatment for hypoxemia may reduce the frequency of this and other complications of the disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/101/3/846/1258313/h80303000846.pdf

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