Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu-Reference-Cited by-同舟云学术

Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu

Published:2018-11-01 Issue:18 Volume:132 Page:1974-1984
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Xuejie¹,Jin Da-Yun¹,Stafford Darrel W.¹,Tie Jian-Ke¹^ORCID

Affiliation:

1. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC

Abstract

Key Points Acenocoumarol is the most efficient oral anticoagulant with the least variation of resistance among naturally occurring VKOR mutations. Warfarin and fluindione are equipotent for anticoagulation control but have different mechanisms of action on VKOR inactivation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/18/1974/1469453/blood846592.pdf

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