Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation

Author:

Pfeifer Heike1,Raum Katharina23,Markovic Sandra1,Nowak Verena2,Fey Stephanie2,Obländer Julia2,Pressler Jovita2,Böhm Verena4,Brüggemann Monika4,Wunderle Lydia1,Hüttmann Andreas5,Wäsch Ralph6,Beck Joachim7,Stelljes Matthias8,Viardot Andreas9,Lang Fabian1,Hoelzer Dieter1,Hofmann Wolf-Karsten2,Serve Hubert1,Weiss Christel10,Goekbuget Nicola1,Ottmann Oliver G.111ORCID,Nowak Daniel2

Affiliation:

1. Department of Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany;

2. Department of Hematology and Oncology and

3. Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;

4. Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;

5. Department of Hematology and Oncology, University Hospital Essen, Essen, Germany;

6. Department of Hematology and Oncology, University Hospital Freiburg, Freiburg, Germany;

7. Department of Hematology and Oncology, University Hospital Mainz, Mainz, Germany;

8. Department of Hematology and Oncology, University Hospital Münster, Münster, Germany;

9. Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany;

10. Department of Biomedical Statistics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; and

11. Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom

Abstract

Key Points Genomic deletions of CDKN2A/2B are a new independent prognostic risk factor in adult Ph+ ALL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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