Clonal chromosomal abnormalities appearing in Philadelphia chromosome–negative metaphases during CML treatment-Reference-Cited by-同舟云学术

Clonal chromosomal abnormalities appearing in Philadelphia chromosome–negative metaphases during CML treatment

Published:2017-11-09 Issue:19 Volume:130 Page:2084-2091
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Issa Ghayas C.¹^ORCID,Kantarjian Hagop M.¹,Gonzalez Graciela Nogueras²,Borthakur Gautam¹,Tang Guilin³,Wierda William¹,Sasaki Koji¹,Short Nicholas J.¹,Ravandi Farhad¹,Kadia Tapan¹,Patel Keyur³,Luthra Raja³,Ferrajoli Alessandra¹,Garcia-Manero Guillermo¹,Rios Mary Beth¹,Dellasala Sara¹,Jabbour Elias¹,Cortes Jorge E.¹

Affiliation:

1. Department of Leukemia,

2. Department of Biostatistics, and

3. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

Key Points Clonal chromosomal abnormalities in Ph− metaphases not including –Y predict decreased FFS, EFS, TFS, and OS in patients with CML. They affect TFS independently of baseline variables, although this is abrogated by inclusion of early response in multivariate models.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/19/2084/1402908/blood792143.pdf

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