Ibrutinib for chronic graft-versus-host disease after failure of prior therapy

Author:

Miklos David1,Cutler Corey S.2,Arora Mukta3,Waller Edmund K.4,Jagasia Madan5,Pusic Iskra6,Flowers Mary E.7,Logan Aaron C.8,Nakamura Ryotaro9,Blazar Bruce R.3,Li Yunfeng10,Chang Stephen10,Lal Indu10,Dubovsky Jason10,James Danelle F.10,Styles Lori10,Jaglowski Samantha11

Affiliation:

1. Stanford University School of Medicine, Stanford, CA;

2. Dana-Farber Cancer Institute, Boston, MA;

3. Department of Medicine, University of Minnesota, Minneapolis, MN;

4. Winship Cancer Institute of Emory University, Atlanta, GA;

5. Vanderbilt-Ingram Cancer Center, Nashville, TN;

6. Division of Oncology, Washington University School of Medicine, St. Louis, MO;

7. Fred Hutchinson Cancer Research Center, Seattle, WA;

8. University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA;

9. City of Hope, Duarte, CA;

10. Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA; and

11. Division of Hematology, The Ohio State University Cancer Center, Columbus, OH

Abstract

Key Points Ibrutinib induced a high rate of sustained responses for patients with cGVHD and inadequate response to corticosteroid-containing therapy. This trial supported the approval of ibrutinib for treatment of adult patients with cGVHD after failure of ≥1 lines of systemic therapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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