Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia

Author:

Bride Karen L.1,Vincent Tiffaney L.1,Im Soo-Yeon1,Aplenc Richard1,Barrett David M.1,Carroll William L.2,Carson Robin3,Dai Yunfeng4,Devidas Meenakshi4,Dunsmore Kimberly P.5,Fuller Tori1,Glisovic-Aplenc Tina1,Horton Terzah M.6,Hunger Stephen P.1,Loh Mignon L.7,Maude Shannon L.1,Raetz Elizabeth A.8,Winter Stuart S.9,Grupp Stephan A.1,Hermiston Michelle L.7,Wood Brent L.10,Teachey David T.1

Affiliation:

1. Division of Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

2. Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York University, New York, NY;

3. Janssen Biotech, Horsham, PA;

4. Department of Biostatistics, University of Florida, Gainesville, FL;

5. Carilion Children’s Clinic, Roanoke, VA;

6. Baylor College of Medicine Dan L. Duncan Comprehensive Cancer Center, Houston, TX;

7. Division of Hematology/Oncology, University of California San Francisco Benioff Children’s Hospital, San Francisco, CA;

8. Department of Pediatrics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT;

9. Children's Minnesota Cancer and Blood Disorders, Minneapolis, MN; and

10. Seattle Children’s Hospital, Seattle, WA

Abstract

Key Points Daratumumab is effective against T-ALL in human xenograft models. CD38 is a novel target with broad potential in the treatment of T-ALL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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