Integrated molecular profiling of juvenile myelomonocytic leukemia

Author:

Murakami Norihiro1,Okuno Yusuke2,Yoshida Kenichi3,Shiraishi Yuichi4,Nagae Genta5,Suzuki Kyogo1,Narita Atsushi1,Sakaguchi Hirotoshi6,Kawashima Nozomu1,Wang Xinan1,Xu Yinyan1,Chiba Kenichi4,Tanaka Hiroko4,Hama Asahito1,Sanada Masashi37,Ito Masafumi8,Hirayama Masashi9,Watanabe Arata9,Ueno Toshihide10,Kojima Seiji1,Aburatani Hiroyuki5,Mano Hiroyuki10,Miyano Satoru411,Ogawa Seishi3,Takahashi Yoshiyuki1,Muramatsu Hideki1

Affiliation:

1. Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan;

2. Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan;

3. Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;

4. Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science and

5. Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan;

6. Department of Pediatric Hematology/Oncology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan;

7. Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan;

8. Department of Pathology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan;

9. Deparment of Pediatrics, Nakadori General Hospital, Akita, Japan; and

10. Department of Cellular Signaling, Graduate School of Medicine and

11. Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Abstract

Key Points Targetable ALK/ROS1 tyrosine kinase fusions were detected in JMML patients without canonical RAS pathway mutations. Genome-wide methylation analysis identified the hypermethylation profile associated with poor clinical outcome.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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