Expression of TP53 is associated with the outcome of MCL independent of MIPI and Ki-67 in trials of the European MCL Network

Author:

Aukema Sietse M.1ORCID,Hoster Eva23,Rosenwald Andreas45,Canoni Danielle6,Delfau-Larue Marie-Hélène789,Rymkiewicz Grzegorz10,Thorns Christoph11,Hartmann Sylvia12,Kluin-Nelemans Hanneke13,Hermine Olivier1415,Dreyling Martin2,Klapper Wolfram1ORCID

Affiliation:

1. Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, Kiel, Germany;

2. Department of Internal Medicine III, University Hospital Munich, Munich, Germany;

3. Institute of Medical Information Processing, Biometry, and Epidemiology, University of Munich, Munich, Germany;

4. Institute of Pathology, University of Wurzburg, Wurzburg, Germany;

5. Comprehensive Cancer Center Mainfranken, Wurzburg, Germany;

6. Department of Pathology, Necker Hospital, Public Assistance – Hospital of Paris, University Paris Descartes, Paris, France;

7. Department of Biological Hematology and Immunology, Public Assistance – Hospital of Paris, Henri Mondor Hospital Group, Creteil, France;

8. Mondor Institute of Biomedical Research-INSERM U955, Team 9, Henri Mondor Hospital, Creteil, France;

9. Université Paris-Est, Creteil, France;

10. Department of Pathology and Laboratory Diagnostics, Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland;

11. Department of Pathology, University Hospital Schleswig-Holstein, Lubeck, Germany;

12. Department of Pathology, University Hospital of Frankfurt, Frankfurt, Germany;

13. Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

14. Department of Hematology, Necker Hospital, Public Assistance – Hospital of Paris, University Paris Descartes, Paris, France; and

15. Imagine Institute, University of Sorbonne Paris City, Paris, France

Abstract

Key Points TP53 expression (>50% positive cells) has shorter TTF and poor OS independent of both MIPI score and Ki67 index.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 115 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3