Platelets from donors with consistently low HLA-B8, -B12, or -B35 expression do not undergo antibody-mediated internalization-Reference-Cited by-同舟云学术

Platelets from donors with consistently low HLA-B8, -B12, or -B35 expression do not undergo antibody-mediated internalization

Published:2018-01-04 Issue:1 Volume:131 Page:144-152
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Saris Anno¹²,Tomson Bert³,Brand Anneke⁴,Mulder Arend⁴,Claas Frans H.⁴,Lorinser Jos⁵,Scharenberg John¹²,van Ham S. Marieke¹²,ten Brinke Anja¹²,Zwaginga Jaap Jan⁴⁶⁷,van der Meer Pieter F.⁵⁶⁷

Affiliation:

1. Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands;

2. Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;

3. Department of Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands;

4. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands;

5. Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, The Netherlands;

6. Center for Clinical Transfusion Research, Sanquin Research, Leiden, The Netherlands; and

7. Jon J van Rood Center for Clinical Transfusion Science, Leiden University Medical Center, Leiden, The Netherlands

Abstract

Key Points HLA-B8, -B12, or -B35 expression on platelets varies significantly between donors and in certain donors is consistently low or undetectable. Antibody-mediated internalization of platelets correlates with antigen expression and is absent in platelets with low HLA expression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/1/144/1367578/blood799270.pdf

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