Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model-Reference-Cited by-同舟云学术

Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model

Published:2018-01-11 Issue:2 Volume:131 Page:236-246
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Garcia-Santos Daniel¹²^ORCID,Hamdi Amel¹²^ORCID,Saxova Zuzana³,Fillebeen Carine¹²,Pantopoulos Kostas¹²,Horvathova Monika³,Ponka Prem¹²^ORCID

Affiliation:

1. Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada;

2. Department of Physiology, McGill University, Montreal, QC, Canada; and

3. Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

Abstract

Key Points Iron released from heme by HO 1 contributes to the pathophysiology of thalassemia. Inhibition of HO 1 is of therapeutic value for the treatment of thalassemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/2/236/1406293/blood798728.pdf

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4. The heme oxygenase system: a regulator of second messenger gases;Maines;Annu Rev Pharmacol Toxicol,1997

5. The heme oxygenase system: update 2005;Maines;Antioxid Redox Signal,2005

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