BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells-Reference-Cited by-同舟云学术

BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells

Published:2011-07-21 Issue:3 Volume:118 Page:609-617
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Defays Axel¹²³,David Alexandre¹²³,de Gassart Aude¹²³,De Angelis Rigotti Francesca¹²³,Wenger Till¹²³,Camossetto Voahirana¹²³,Brousset Pierre⁴,Petrella Tony⁵,Dalod Marc¹²³,Gatti Evelina¹²³,Pierre Philippe¹²³

Affiliation:

1. Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille, France;

2. Inserm, Marseille, France;

3. Centre National de la Recherche Scientifique, Marseille, France;

4. Inserm, Toulouse, France; and

5. Centre de Pathologie, Dijon, France

Abstract

Abstract The brain and dendritic cell (BAD)–associated lysosome-associated membrane protein (LAMP)–like molecule (BAD-LAMP, c20orf103, UNC-46) is a newly identified member of the family of LAMPs. BAD-LAMP expression in the mouse is confined to neurons. We demonstrate here that in humans, BAD-LAMP can specifically be found in the type I IFN-producing plasmacytoid dendritic cells (pDCs). Human BAD-LAMP is localized in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of freshly isolated CD123+ pDCs and is rapidly lost upon activation by unmethylated cytosine-phosphate-guanine (CpG) oligonucleotides. The restricted pattern of BAD-LAMP expression allows for the rapid identification of normal and leukemic human pDCs in tissues and blood.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/118/3/609/1346671/zh802911000609.pdf

Reference40 articles.

1. Plasmacytoid dendritic cells in immunity.;Colonna;Nat Immunol,2004

2. Liu YJIPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.;Annu Rev Immunol,2005

3. Molecular characterization of human plasmacytoid dendritic cells.;Cao;J Clin Immunol,2009

4. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases.;Gilliet;Nat Rev Immunol,2008

5. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.;Ochando;Nat Immunol,2006

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