A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia-Reference-Cited by-同舟云学术

A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia

Published:2011-01-06 Issue:1 Volume:117 Page:242-245
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Such Esperanza¹,Cervera José¹,Valencia Ana¹,Barragán Eva²,Ibañez Mariam¹,Luna Irene¹,Fuster Óscar²,Perez-Sirvent Maria Luz¹,Senent Leonor¹,Sempere Amparo¹,Martinez Jesús¹,Martín-Aragonés Guillermo¹,Sanz Miguel A.¹

Affiliation:

1. Departments of Hematology and

2. Medical Pathology, Hospital Universitario La Fe, Valencia, Spain

Abstract

Abstract Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/117/1/242/1336414/zh800111000242.pdf

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