Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Author:

Geer Mitchell J.1ORCID,van Geffen Johanna P.2,Gopalasingam Piraveen3ORCID,Vögtle Timo1,Smith Christopher W.1,Heising Silke1,Kuijpers Marijke J. E.2ORCID,Tullemans Bibian M. E.2,Jarvis Gavin E.4ORCID,Eble Johannes A.5,Jeeves Mark3ORCID,Overduin Michael3ORCID,Heemskerk Johan W. M.2,Mazharian Alexandra1ORCID,Senis Yotis A.1ORCID

Affiliation:

1. Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;

2. Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands;

3. Henry Wellcome Building for Biomolecular NMR Spectroscopy, University of Birmingham, Birmingham, United Kingdom;

4. Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom; and

5. Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany

Abstract

Publisher's Note: There is a Blood Commentary on this article in this issue.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference27 articles.

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