The calcineurin-NFAT pathway negatively regulates megakaryopoiesis-Reference-Cited by-同舟云学术

The calcineurin-NFAT pathway negatively regulates megakaryopoiesis

Published:2013-04-18 Issue:16 Volume:121 Page:3205-3215
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zaslavsky Alexander¹,Chou Stella T.²,Schadler Keri¹,Lieberman Allyson¹,Pimkin Maxim²,Kim Yeo Jung¹,Baek Kwan-Hyuck¹³,Aird William C.⁴,Weiss Mitchell J.²,Ryeom Sandra¹

Affiliation:

1. Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA;

2. Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA;

3. Department of Molecular and Cellular Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Jangan-gu, Suwon, GY, Korea; and

4. Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA

Abstract

Key Points Inhibition of calcineurin-NFAT signaling increases megakaryocyte and platelet counts. Inhibition of calcineurin-NFAT signaling increases proliferation of megakaryocyte progenitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/16/3205/1330069/3205.pdf

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