Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex-Reference-Cited by-同舟云学术

Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex

Published:2013-02-21 Issue:8 Volume:121 Page:1413-1421
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gao Chong¹,Dimitrov Todor¹,Yong Kol Jia²,Tatetsu Hiro¹,Jeong Ha-won¹,Luo Hongbo R.³,Bradner James E.⁴,Tenen Daniel G.²⁵,Chai Li¹

Affiliation:

1. Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;

2. Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore;

3. Department of Laboratory Medicine, Children's Hospital Boston, Harvard Medical School, Boston MA;

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; and

5. Harvard Stem Cell Institute, Boston, MA

Abstract

Key PointsThe SALL4/NuRD/PTEN pathway is important for acute myeloid leukemogenesis. Targeting AML can be achieved by blocking the interaction between transcription factor SALL4 and the epigenetic NuRD complex.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/8/1413/1368600/zh800813001413.pdf

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4. Medaka spalt acts as a target gene of hedgehog signaling.;Koster;Development,1997

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