Intracellular NAD+ depletion enhances bortezomib-induced anti-myeloma activity-Reference-Cited by-同舟云学术

Intracellular NAD+ depletion enhances bortezomib-induced anti-myeloma activity

Published:2013-08-15 Issue:7 Volume:122 Page:1243-1255
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cagnetta Antonia¹²,Cea Michele¹²,Calimeri Teresa¹,Acharya Chirag¹,Fulciniti Mariateresa¹,Tai Yu-Tzu¹,Hideshima Teru¹,Chauhan Dharminder¹,Zhong Mike Y.¹,Patrone Franco³,Nencioni Alessio³,Gobbi Marco²,Richardson Paul¹,Munshi Nikhil¹,Anderson Kenneth C.¹

Affiliation:

1. LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and

2. Department of Hematology and Oncology, and

3. Departments of Internal Medicine, Istituto Di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-IST, Genova, Italy

Abstract

Key PointsFK866 combined with bortezomib induces synergistic anti-MM cell death. Addition of low doses of NAD+-depleting agent FK866 overcomes bortezomib resistance in MM cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/7/1243/1374245/1243.pdf

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