Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma-Reference-Cited by-同舟云学术

Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma

Published:2013-09-19 Issue:12 Volume:122 Page:2104-2113
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Amengual Jennifer E.¹,Clark-Garvey Sean¹,Kalac Matko¹,Scotto Luigi¹,Marchi Enrica²,Neylon Ellen¹,Johannet Paul¹,Wei Ying³,Zain Jasmine¹,O’Connor Owen A.¹

Affiliation:

1. Center for Lymphoid Malignancies, Columbia University, New York, NY;

2. Department of Medicine, Lincoln Medical Center, New York, NY; and

3. Mailman School of Public Health, Columbia University, New York, NY

Abstract

Key Points Treatment of DLBCL with the combination of sirtuin and DAC inhibitors leads to synergistic cytotoxicity and acetylation of Bcl6 and p53. The overall response rate of relapsed lymphoma patients treated with vorinostat and niacinamide was 24%, and an additional 57% achieved stable disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/12/2104/1369349/2104.pdf

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