PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1-Reference-Cited by-同舟云学术

PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1

Published:2014-01-09 Issue:2 Volume:123 Page:261-270
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wu Jie¹²,Zhou Li-Quan¹,Yu Wei¹,Zhao Zhi-Guo¹,Xie Xue-Min¹,Wang Wen-Tian¹,Xiong Jian¹,Li Man¹,Xue Zheng¹,Wang Xing¹,Zhang Peng¹,Mao Bei-Bei¹,Hao De-Long¹,Lv Xiang¹,Liu De-Pei¹

Affiliation:

1. State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, and

2. Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Republic of China

Abstract

Key Points PML4 promotes erythroid differentiation in K562, primary erythroid cells, and GATA-1–rescued G1E-ER4 cells, but not in GATA-1–deficient G1E cells. PML4 interacts with GATA-1 and enhances its transcriptional activity by stimulating GATA-1/P300 cooperation and GATA-1 acetylation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/2/261/1377166/261.pdf

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5. CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites.;Hung;Mol Cell Biol,1999

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