Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality-Reference-Cited by-同舟云学术

Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality

Published:2013-08-22 Issue:8 Volume:122 Page:1505-1509
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Levine John E.¹,Huber Elisabeth²,Hammer Suntrea T. G.³,Harris Andrew C.¹,Greenson Joel K.³,Braun Thomas M.⁴,Ferrara James L. M.¹,Holler Ernst⁵

Affiliation:

1. Department of Pediatrics, University of Michigan, Ann Arbor, MI;

2. Institute of Pathology, University of Regensburg, Regensburg, Germany;

3. Department of Pathology and

4. Department of Biostatistics, University of Michigan, Ann Arbor, MI; and

5. Department of Hematology/Oncology, University Medical Center Regensburg, Regensburg, Germany

Abstract

Key Points Paneth cell numbers in the duodenum at onset of GVHD correlate with outcomes. Paneth cells are easy to identify and quantify with light microscopy and may supplement histopathological grading of GI GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/8/1505/1374487/1505.pdf

Reference21 articles.

1. Graft-versus-host disease.;Ferrara;Lancet,2009

2. Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.;Ferrara;Blood,2011

3. What predicts high risk acute graft-versus-host disease (GVHD) at onset?: identification of those at highest risk by a novel acute GVHD risk score.;MacMillan;Br J Haematol,2012

4. IBMTR severity index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade.;Rowlings;Br J Haematol,1997

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