The β2 integrin–kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo-Reference-Cited by-同舟云学术

The β2 integrin–kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

Published:2013-08-22 Issue:8 Volume:122 Page:1428-1436
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Morrison Vicky Louise¹,MacPherson Matthew¹,Savinko Terhi²,San Lek Hwee¹,Prescott Alan³,Fagerholm Susanna Carola¹²

Affiliation:

1. Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom;

2. Institute of Biotechnology, University of Helsinki, Helsinki, Finland; and

3. College of Life Sciences, University of Dundee, Dundee, United Kingdom

Abstract

Key Points TTT-motif in beta2-integrin binds kindlin-3. Mutation of TTT-motif affects T-cell homing not activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/8/1428/1373939/1428.pdf

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5. The dependence for leukocyte function-associated antigen-1/ICAM-1 interactions in T cell activation cannot be overcome by expression of high density TCR ligand.;Abraham;J Immunol,1999

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