Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines-Reference-Cited by-同舟云学术

Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines

Published:2013-09-19 Issue:12 Volume:122 Page:2047-2051
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mills Jason A.¹,Wang Kai²,Paluru Prasuna¹,Ying Lei¹,Lu Lin¹,Galvão Aline M.¹,Xu Dongbin³,Yao Yu⁴,Sullivan Spencer K.⁴,Sullivan Lisa M.¹,Mac Helen¹,Omari Amel⁵,Jean Jyh-Chang⁵,Shen Steve⁶,Gower Adam⁶,Spira Avi⁶,Mostoslavsky Gustavo⁵,Kotton Darrell N.⁵,French Deborah L.¹,Weiss Mitchell J.⁴,Gadue Paul¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA;

2. Zilkha Neurogenetic Institute, Department of Psychiatry and Preventive Medicine, University of Southern California, Los Angeles, CA;

3. Division of Human Genetics, and

4. Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA; and

5. Department of Medicine and Center for Regenerative Medicine, and

6. Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA

Abstract

Key Points Normal induced pluripotent stem cells exhibit donor-specific gene expression signatures and the capacity for hematopoietic development. CNVs acquired during reprogramming or selection of rare CNVs present in the starting cell population may alter iPSC developmental potential.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/12/2047/1369227/2047.pdf

Reference19 articles.

1. Variation in hematopoietic potential of induced pluripotent stem cell lines.;Kulkeaw;Stem Cell Rev,2010

2. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).;Tolar;Blood,2011

3. Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting.;Zou;Blood,2011

4. Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.;Jiang;Stem Cells,2012

5. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.;Takayama;J Exp Med,2010

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