Bacillus anthracis peptidoglycan activates human platelets through FcγRII and complement-Reference-Cited by-同舟云学术

Bacillus anthracis peptidoglycan activates human platelets through FcγRII and complement

Published:2013-07-25 Issue:4 Volume:122 Page:571-579
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sun Dawei¹²,Popescu Narcis I.³,Raisley Brent²,Keshari Ravi S.³,Dale George L.⁴,Lupu Florea³,Coggeshall K. Mark¹²

Affiliation:

1. Department of Cell Biology, University of Oklahoma, Oklahoma City, OK;

2. Immunobiology and Cancer Program and

3. Cardiovascular Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; and

4. Department of Medicine, University of Oklahoma, Oklahoma City, OK

Abstract

Key Points PGN forms immune complexes with preexisting human anti-PGN antibodies to activate the classical complement pathway. Human platelets are activated by PGN–anti-PGN immune complexes through platelet FcγRIIa and through platelet binding C5b.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/4/571/1373055/571.pdf

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