Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function-Reference-Cited by-同舟云学术

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

Published:2013-10-10 Issue:15 Volume:122 Page:2664-2672
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Coelho Vânia¹,Krysov Sergey²,Steele Andrew²,Sanchez Hidalgo Marina³,Johnson Peter W.⁴,Chana Prabhjoat S.⁵,Packham Graham²,Stevenson Freda K.⁶,Forconi Francesco¹⁷

Affiliation:

1. Haematology Oncology Group,

2. Molecular Oncology Group, Cancer Sciences Unit, Cancer Research UK Centre, University of Southampton Faculty of Medicine, Southampton, United Kingdom;

3. Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain;

4. Medical Oncology, University Hospital Southampton National Health Service Trust, Southampton, United Kingdom;

5. Biomedical Research Centre of Guy’s and St. Thomas’ National Health Service Foundation Trust and King’s College London, London, United Kingdom;

6. Molecular Immunology Group, Cancer Sciences Unit, Cancer Research UK Centre, University of Southampton Faculty of Medicine, Southampton, United Kingdom; and

7. Haematology Department, University Hospital Southampton National Health Service Trust, Southampton, United Kingdom

Abstract

Key Points The study reveals that circulating CLL cells contain intraclonal subgroups that differ in the level of signal-responsive surface IgM. Subgroups with higher surface IgM express more CXCR4, potentially predicting a dangerous ability to migrate to tissue and engage antigen.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/15/2664/1369711/2664.pdf

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