Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance-Reference-Cited by-同舟云学术

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance

Published:2013-09-05 Issue:10 Volume:122 Page:1741-1745
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Guitart Amelie V.¹²,Subramani Chithra¹²,Armesilla-Diaz Alejandro¹²,Smith Gillian¹²,Sepulveda Catarina¹²,Gezer Deniz¹²,Vukovic Milica¹²,Dunn Karen²,Pollard Patrick³,Holyoake Tessa L.²,Enver Tariq⁴,Ratcliffe Peter J.³,Kranc Kamil R.¹²

Affiliation:

1. Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom;

2. Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom;

3. Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; and

4. Stem Cell Laboratory, UCL Cancer Institute, University College London, London, United Kingdom

Abstract

Key Points Hif-2α–dependent signaling is dispensable for steady-state multilineage hematopoiesis. Hif-2α is not essential for HSC self-renewal.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/10/1741/1368075/1741.pdf

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4. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.;Takubo;Cell Stem Cell,2010

5. Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells.;Kocabas;Blood,2012

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