Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing-Reference-Cited by-同舟云学术

Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing

Published:2013-08-15 Issue:7 Volume:122 Page:1256-1265
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Morin Ryan D.¹²,Mungall Karen¹,Pleasance Erin¹,Mungall Andrew J.¹,Goya Rodrigo¹,Huff Ryan D.¹,Scott David W.³,Ding Jiarui⁴,Roth Andrew⁴,Chiu Readman¹,Corbett Richard D.¹,Chan Fong Chun³,Mendez-Lago Maria¹,Trinh Diane L.¹⁵,Bolger-Munro Madison¹,Taylor Greg¹,Hadj Khodabakhshi Alireza¹,Ben-Neriah Susana³,Pon Julia¹,Meissner Barbara³,Woolcock Bruce³,Farnoud Noushin¹,Rogic Sanja³,Lim Emilia L.¹,Johnson Nathalie A.⁶,Shah Sohrab⁴⁷,Jones Steven¹²,Steidl Christian³⁷,Holt Robert¹²,Birol Inanc¹⁵,Moore Richard¹,Connors Joseph M.³,Gascoyne Randy D.³⁷,Marra Marco A.¹⁵

Affiliation:

1. Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada;

2. Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada;

3. Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, Canada;

4. Department of Computer Science and

5. Department of Medical Genetics, University of British Columbia, Vancouver, Canada;

6. Department of Medicine and Department of Oncology, McGill University, Jewish General Hospital, Montreal, Canada; and

7. Department of Pathology, University of British Columbia, Vancouver, Canada

Abstract

Key Points Complete genome sequence analysis of 40 DLBCL tumors and 13 cell lines reveals novel somatic point mutations, rearrangements, and fusions. Recurrence of mutations in genes involved in B-cell homing were identified in germinal center B-cell DLBCLs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/7/1256/1373480/1256.pdf

Reference49 articles.

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2. Analysis of the coding genome of diffuse large B-cell lymphoma.;Pasqualucci;Nat Genet,2011

3. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.;Lohr;Proc Natl Acad Sci USA,2012

4. Genetic heterogeneity of diffuse large B-cell lymphoma.;Zhang;Proc Natl Acad Sci USA,2013

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