Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation

Author:

Fernández-Viña Marcelo A.1,Klein John P.2,Haagenson Michael3,Spellman Stephen R.3,Anasetti Claudio4,Noreen Harriet5,Baxter-Lowe Lee Ann6,Cano Pedro7,Flomenberg Neal8,Confer Dennis L.9,Horowitz Mary M.2,Oudshoorn Machteld10,Petersdorf Effie W.11,Setterholm Michelle9,Champlin Richard7,Lee Stephanie J.11,de Lima Marcos12

Affiliation:

1. Department of Pathology, Stanford Medical School Blood Center, Stanford, CA;

2. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, WI;

3. Center for International Blood and Marrow Transplant Research, Minneapolis, MN;

4. Blood and Marrow Transplant, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

5. University of Minnesota Medical Center, Fairview, Minneapolis, MN;

6. University of California Medical Center, San Francisco, CA;

7. MD Anderson Cancer Research Center, Houston, TX;

8. Department of Medical Oncology, Jefferson University, Philadelphia, PA;

9. National Marrow Donor Program, Minneapolis, MN;

10. Europdonor Foundation, Leiden University Medical Center, Leiden, The Netherlands;

11. Fred Hutchinson Cancer Research Center, Seattle, WA; and

12. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH

Abstract

Key Points Three or more mismatches at the Low Expression Loci may adversely affect clinical outcome after 7/8 matched transplantation. Match grade at the Low Expression HLA Loci may be considered to select 7/8 donors with potentially lower posttransplant risks.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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