Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia-Reference-Cited by-同舟云学术

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

Published:2014-04-17 Issue:16 Volume:123 Page:2518-2529
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

He Bai-Liang¹,Shi Xiangguo¹,Man Cheuk Him¹,Ma Alvin C. H.¹²,Ekker Stephen C.²,Chow Howard C. H.¹,So Chi Wai Eric³,Choi William W. L.⁴,Zhang Wenqing⁵,Zhang Yiyue⁵,Leung Anskar Y. H.¹

Affiliation:

1. Division of Haematology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong;

2. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN;

3. Department of Haematological Medicine, King’s College London, London, United Kingdom;

4. Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; and

5. Department of Cell Biology, Southern Medical University, Guangzhou, China

Abstract

Key Points Zebrafish flt3 plays an important role in the initiation of definitive hematopoietic stem cells. Expression of human FLT3-ITD activates endogenous flt3 signaling and induces myeloid expansion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/16/2518/1376137/2518.pdf

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5. Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish.;Meijer;Dev Comp Immunol,2008

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