Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity-Reference-Cited by-同舟云学术

Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity

Published:2013-06-06 Issue:23 Volume:121 Page:4694-4702
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rudnicka Dominika¹,Oszmiana Anna²,Finch Donna K.³,Strickland Ian³,Schofield Darren J.³,Lowe David C.³,Sleeman Matthew A.³,Davis Daniel M.¹²

Affiliation:

1. Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom;

2. Manchester Collaborative Centre for Inflammation Research, Core Technology Facility, University of Manchester, Manchester, United Kingdom; and

3. MedImmune Ltd, Cambridge, United Kingdom

Abstract

Key Points Rituximab causes a polarization of B cells, involving a reorganization of CD20, intercellular adhesion molecule 1, and moesin, and orientation of the microtubule organizing center. The polarization of B cells induced by rituximab augments its therapeutic role in triggering ADCC by effector NK cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/23/4694/1366097/4694.pdf

Reference27 articles.

1. Rituximab: a review of its use in chronic lymphocytic leukaemia, low-grade or follicular lymphoma and diffuse large B-cell lymphoma.;Keating;Drugs,2010

2. Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion.;Leandro;Ann Rheum Dis,2002

3. IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin’s lymphoma.;Maloney;Blood,1997

4. A unique cell surface antigen identifying lymphoid malignancies of B cell origin.;Nadler;J Clin Invest,1981

5. The mechanisms of action of rituximab in the elimination of tumor cells.;Johnson;Semin Oncol,2003

Cited by 79 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antibody surface mobility amplifies FcγR signaling via Arp2/3 during phagocytosis;Biophysical Journal;2024-08

2. Using adjusted local assortativity with Molecular Pixelation unveils colocalization of membrane proteins with immunological significance;Frontiers in Immunology;2024-06-25

3. Molecular pixelation: spatial proteomics of single cells by sequencing;Nature Methods;2024-05-08

4. The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples;International Journal of Molecular Sciences;2024-05-06

5. Sonrotoclax overcomes BCL2 G101V mutation–induced venetoclax resistance in preclinical models of hematologic malignancy;Blood;2024-05-02