Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis

Author:

Cervantes Francisco1,Vannucchi Alessandro M.2,Kiladjian Jean-Jacques3,Al-Ali Haifa Kathrin4,Sirulnik Andres5,Stalbovskaya Viktoriya6,McQuitty Mari6,Hunter Deborah S.7,Levy Richard S.7,Passamonti Francesco8,Barbui Tiziano9,Barosi Giovanni10,Harrison Claire N.11,Knoops Laurent12,Gisslinger Heinz13

Affiliation:

1. Hospital Clínic, Hematology Department, Institut d'Investigació Biomédica August Pi i Sunyer, University of Barcelona, Barcelona, Spain;

2. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy;

3. The Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Louis, Centre d'Investigations Cliniques and Department of Clinical Pharmacology, Université Paris Diderot, Paris, France;

4. Division of Hematology and Medical Oncology, University of Leipzig, Leipzig, Germany;

5. Novartis Clinical Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ;

6. Oncology Global Development, Novartis Pharma AG, Basel, Switzerland;

7. Clinical Development, Incyte Corporation, Wilmington, DE;

8. Department of Hematology, Ospedale di Circolo e Fondazione Macchi, Varese, Italy;

9. Department of Hematology, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy;

10. Center for the Study of Myelofibrosis, Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy;

11. Department of Haematology, Guy’s and St. Thomas’ National Health Service Foundation Trust, London, United Kingdom;

12. Hematology Unit, Cliniques Universitaires Saint-Luc and de Duve Institute, Université Catholique de Louvain, Brussels, Belgium; and

13. Department of Internal Medicine, Medical University of Vienna, Vienna, Austria

Abstract

Key Points Long-term analysis of the COMFORT-II Trial shows that ruxolitinib treatment results in durable reductions in splenomegaly and is well tolerated. Patients randomized to ruxolitinib showed longer overall survival than those receiving the BAT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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