Structure of an extended β3 integrin-Reference-Cited by-同舟云学术

Structure of an extended β3 integrin

Published:2018-08-30 Issue:9 Volume:132 Page:962-972
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhou Dongwen¹,Thinn Aye Myat Myat¹²,Zhao Yan¹³,Wang Zhengli¹,Zhu Jieqing¹²

Affiliation:

1. Blood Research Institute, BloodCenter of Wisconsin, part of Versiti, Milwaukee, WI;

2. Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI; and

3. Department of Physiology, School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Abstract

Key Points Conformational extension is essential for integrin to fulfill its cell-adhesion function in platelet-mediated hemostasis and thrombosis. High-resolution structures of β3 integrin in intermediate and extended conformations reveal atomic-level conformational rearrangements.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/9/962/1467270/blood829572.pdf

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