Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A-Reference-Cited by-同舟云学术

Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A

Author:

Buscarlet Manuel¹,Provost Sylvie²,Zada Yassamin Feroz²,Bourgoin Vincent¹,Mollica Luigina¹³⁴,Dubé Marie-Pierre²⁴,Busque Lambert¹³⁴

Affiliation:

1. Research Center, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada;

2. Beaulieu-Saucier Pharmacogenomics Center, Montreal Heart Institute Research Center, Montréal, QC, Canada;

3. Hematology Division, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada; and

4. Faculty of Medicine, Université de Montréal, Montréal, QC, Canada

Abstract

Key Points TET2 mutations confer a myeloid proliferation bias. DNMT3A mutations occur in a multipotent stem cell.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

Reference19 articles.

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