CALGB 50604: risk-adapted treatment of nonbulky early-stage Hodgkin lymphoma based on interim PET

Author:

Straus David J.12,Jung Sin-Ho3,Pitcher Brandelyn3,Kostakoglu Lale4,Grecula John C.5,Hsi Eric D.6,Schöder Heiko12,Popplewell Leslie L.7,Chang Julie E.8,Moskowitz Craig H.12,Wagner-Johnston Nina9,Leonard John P.2,Friedberg Jonathan W.10,Kahl Brad S.9,Cheson Bruce D.11,Bartlett Nancy L.9

Affiliation:

1. Memorial Sloan Kettering Cancer Center, New York, NY;

2. John P. Leonard Department of Medicine, Weill Cornell Medicine, New York, NY;

3. Alliance Statistics and Data Center, Duke University, Durham, NC;

4. Department of Radiology, Mount Sinai Medical School, New York, NY;

5. Department of Radiation Oncology, Ohio State University Medical Center, Columbus, OH;

6. Cleveland Clinic, Cleveland, OH;

7. City of Hope, Duarte, CA;

8. University of Wisconsin School of Medicine and Public Health, Madison, WI;

9. Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO;

10. University of Rochester Medical Center, Rochester, NY; and

11. Georgetown University Hospital, Washington, DC

Abstract

Key Points Interim PET− nonbulky stage I/II patients had 3-year PFS of 91% with 4 ABVD cycles and no RT. Too few patients were interim PET+ to draw firm conclusions about efficacy of escalated BEACOPP plus involved-field RT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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