miR-155 promotes FLT3-ITD–induced myeloproliferative disease through inhibition of the interferon response-Reference-Cited by-同舟云学术

miR-155 promotes FLT3-ITD–induced myeloproliferative disease through inhibition of the interferon response

Published:2017-06-08 Issue:23 Volume:129 Page:3074-3086
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wallace Jared A.¹,Kagele Dominique A.¹,Eiring Anna M.²,Kim Carissa N.¹,Hu Ruozhen¹,Runtsch Marah C.¹,Alexander Margaret¹,Huffaker Thomas B.¹,Lee Soh-Hyun¹,Patel Ami B.²,Mosbruger Timothy L.²,Voth Warren P.¹,Rao Dinesh S.³,Miles Rodney R.¹²,Round June L.¹,Deininger Michael W.²⁴,O’Connell Ryan M.¹

Affiliation:

1. Department of Pathology and

2. Huntsman Cancer Institute, University of Utah, Salt Lake City, UT;

3. Department of Pathology, University of California Los Angeles, Los Angeles, CA; and

4. Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT

Abstract

Key Points miR-155 promotes myeloproliferation in the bone marrow, spleen, and blood of mice carrying the FLT3-ITD mutation. miR-155 suppresses the IFN response in FLT3-ITD+ mouse hematopoietic stem and progenitor cells, as well as FLT3-ITD+ human AML cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/23/3074/1400895/blood740209.pdf

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