Plasmin and plasminogen induce macrophage reprogramming and regulate key steps of inflammation resolution via annexin A1

Author:

Sugimoto Michelle A.123ORCID,Ribeiro Ana Luíza C.134,Costa Bruno R. C.134ORCID,Vago Juliana P.13ORCID,Lima Kátia M.13,Carneiro Fernanda S.13ORCID,Ortiz Mylena Maira O.13,Lima Graziele Letícia N.13ORCID,Carmo Aline A. F.13ORCID,Rocha Renata M.3ORCID,Perez Denise A.3,Reis Alessandra C.3ORCID,Pinho Vanessa3ORCID,Miles Lindsey A.5,Garcia Cristiana C.6ORCID,Teixeira Mauro M.3ORCID,Sousa Lirlândia P.1234ORCID

Affiliation:

1. Signaling in Inflammation Laboratory, Department of Clinical and Toxicological Analyses,

2. Postgraduate Program in Pharmaceutical Sciences, School of Pharmacy,

3. Immunopharmacology Laboratory, Department of Biochemistry and Immunology, Institute of Biological Sciences, and

4. Postgraduate Program in Clinical and Toxicological Analyses, Department of Clinical and Toxicological Analyses, School of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;

5. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA; and

6. Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Rio de Janeiro, Brazil

Abstract

Key Points Plg and Pla induce macrophage reprogramming and promote resolution of acute inflammation. Plg and Pla enhance the efferocytic capacity of macrophages and override the prosurvival effect of LPS on neutrophils via annexin A1.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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