Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke-Reference-Cited by-同舟云学术

Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke

Published:2017-04-20 Issue:16 Volume:129 Page:2280-2290
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Simão Fabrício¹^ORCID,Ustunkaya Tuna¹,Clermont Allen C.¹,Feener Edward P.¹^ORCID

Affiliation:

1. Research Division, Vascular Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA

Abstract

Key Points tPA activates the contact system, and PKal blockade enhances tPA-mediated thrombolysis. PKal contributes to hemorrhagic transformation and cerebral edema in mice with acute stroke receiving tPA.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/16/2280/1400066/blood740670.pdf

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