B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)–infected patients rarely react with the viral proteins

Author:

Ng Patrick P.1,Kuo Chiung-Chi1,Wang Stanley1,Einav Shirit1,Arcaini Luca2,Paulli Marco2,Portlock Carol S.3,Marcotrigiano Joseph4,Tarr Alexander5,Ball Jonathan5,Levy Ronald1,Levy Shoshana1

Affiliation:

1. Stanford University Medical Center, Stanford, CA;

2. University of Pavia, Pavia, Italy;

3. Memorial Sloan-Kettering Cancer Center, New York, NY;

4. Rutgers University, Piscataway, NJ; and

5. University of Nottingham, Nottingham, United Kingdom

Abstract

Key Points We tested the hypothesis that B-cell lymphomas arising in HCV-infected patients express B-cell receptors specific to the virus. We analyzed the reactivity of these B-cell receptors with HCV proteins using several experimental approaches, none of which supported the hypothesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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