Increased BCR responsiveness in B cells from patients with chronic GVHD-Reference-Cited by-同舟云学术

Increased BCR responsiveness in B cells from patients with chronic GVHD

Published:2014-03-27 Issue:13 Volume:123 Page:2108-2115
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Allen Jessica L.¹,Tata Prasanthi V.²,Fore Matthew S.²,Wooten Jenna²,Rudra Sharmistha¹,Deal Allison M.²,Sharf Andrew³,Hoffert Todd⁴,Roehrs Philip A.⁵,Shea Thomas C.³⁶,Serody Jonathan S.³⁷⁸,Richards Kristy L.⁶,Jagasia Madan⁷,Lee Stephanie J.⁹,Rizzieri David¹,Horwitz Mitchell E.¹,Chao Nelson J.¹,Sarantopoulos Stefanie¹

Affiliation:

1. Division of Hematological Malignancies and Cellular Therapy, Duke University Department of Medicine and Duke Cancer Institute, Durham, NC;

2. Lineberger Comprehensive Cancer Center,

3. Bone Marrow and Stem Cell Transplant Program,

4. Hematolymphoid Disorder Tissue Procurement Facility,

5. Pediatric Hematology/Oncology, and

6. Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC;

7. Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN;

8. Immunotherapy Program Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; and

9. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Abstract

Key Points Human cGVHD B cells have increased proximal BCR signaling protein expression and are more BCR responsive than non-cGVHD B cells. Inhibiting Syk kinase activity abrogates the BCR-driven ex vivo proliferative and survival advantage of human chronic GVHD B cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/13/2108/1375289/2108.pdf

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