CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma-Reference-Cited by-同舟云学术

CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

Published:2014-06-12 Issue:24 Volume:123 Page:3770-3779
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Murray Megan E.¹,Gavile Catherine M.²,Nair Jayakumar R.¹,Koorella Chandana¹,Carlson Louise M.¹,Buac Daniela¹,Utley Adam¹,Chesi Marta³,Bergsagel P. Leif³,Boise Lawrence H.²,Lee Kelvin P.¹⁴^ORCID

Affiliation:

1. Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY;

2. The Department of Hematology and Medical Oncology and the Winship Cancer Institute, Emory University, Atlanta, GA;

3. Mayo Clinic Arizona, Comprehensive Cancer Center, Scottsdale, AZ; and

4. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY

Abstract

Key Points CD28 delivers a pro-survival signal to MM cells via regulation of PI3K/Akt, FoxO3a, and Bim. Blockade of CD28:CD80/CD86 in vivo resensitizes MM cells to chemotherapy and significantly reduces tumor burden.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/24/3770/1377334/3770.pdf

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