Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation

Author:

Fernandez-Viña Marcelo A.1,Wang Tao2,Lee Stephanie J.3,Haagenson Michael4,Aljurf Mahmoud5,Askar Medhat6,Battiwalla Minoo7,Baxter-Lowe Lee-Ann8,Gajewski James9,Jakubowski Ann A.10,Marino Susana11,Oudshoorn Machteld12,Marsh Steven G. E.13,Petersdorf Effie W.3,Schultz Kirk14,Turner E. Victoria15,Waller Edmund K.16,Woolfrey Ann3,Umejiego John4,Spellman Stephen R.4,Setterholm Michelle17

Affiliation:

1. Department of Pathology, Stanford University School of Medicine, Stanford, CA;

2. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

3. Fred Hutchinson Cancer Research Center, Seattle, WA;

4. Center for International Blood and Marrow Transplant Research, Minneapolis, MN;

5. King Faisal Cancer Center, Riyadh, Saudi Arabia;

6. Cleveland Clinic Foundation, Cleveland, OH;

7. National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD;

8. San Francisco Medical Center, San Francisco, CA;

9. Oregon Health and Science University, Portland, OR;

10. Memorial Sloan-Kettering Cancer Center, New York, NY;

11. University of Chicago Medicine, Chicago, IL;

12. Europdonor Foundation, Leiden University Medical Center, Leiden, The Netherlands;

13. Anthony Nolan Research Institute and University College London, London, United Kingdom;

14. British Columbia Children’s Hospital, University of British Columbia, Vancouver, BC, Canada;

15. HLA Laboratory, St. Jude Children's Research Hospital, Memphis, TN;

16. Emory University Hospital, Atlanta, GA; and

17. National Marrow Donor Program, Minneapolis, MN

Abstract

Key Points Mismatches in alleles C*03:03/C*03:04 were most frequent (68.7%) among the transplants with a single allele level mismatch in HLA-C. The 7/8 C*03:03/C*03:04 mismatch group was not significantly different from the 8/8 HLA matched transplants in any transplant outcome.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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