Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort

Author:

Hosnijeh Fatemeh Saberi12,Lan Qing3,Rothman Nathaniel3,San Liu Chin45,Cheng Wen-Ling6,Nieters Alexandra7,Guldberg Per8,Tjønneland Anne8,Campa Daniele9,Martino Alessandro9,Boeing Heiner10,Trichopoulou Antonia1112,Lagiou Pagona121314,Trichopoulos Dimitrios111314,Krogh Vittorio15,Tumino Rosario16,Panico Salvatore17,Masala Giovanna18,Weiderpass Elisabete19202122,Huerta Castaño José María2324,Ardanaz Eva2425,Sala Núria26,Dorronsoro Miren27,Quirós J. Ramón28,Sánchez María-José242930,Melin Beatrice31,Johansson Ann Sofie31,Malm Johan3233,Borgquist Signe34,Peeters Petra H.35,Bueno-de-Mesquita H. Bas363738,Wareham Nick3940,Khaw Kay-Tee40,Travis Ruth C.41,Brennan Paul42,Siddiq Afshan43,Riboli Elio44,Vineis Paolo3845,Vermeulen Roel135

Affiliation:

1. Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands;

2. Zanjan University of Medical Sciences, Zanjan, Iran;

3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD;

4. Department of Neurology and Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan;

5. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan;

6. Laboratory of Mitochondrial Medicine, Chunghua Christian Hospital, Taipei, Taiwan;

7. Centre of Chronic Immunodeficiency, University Medical Centre Freiburg, Freiburg, Germany;

8. Danish Cancer Society Research Center, Copenhagen, Denmark;

9. Genomic Epidemiology Group, German Cancer Research Center, Heidelberg, Germany;

10. Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany;

11. Hellenic Health Foundation, Athens, Greece;

12. WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece;

13. Department of Epidemiology, Harvard School of Public Health, Boston, MA;

14. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece;

15. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;

16. Cancer Registry and Histopathology Unit, “Civic - M.P. Arezzo” Hospital, ASP Ragusa, Italy;

17. Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy;

18. Molecular and Nutritional Epidemiology Unit, ISPO Cancer Research and Prevention Institute, Florence, Italy;

19. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway;

20. Department of Research, Cancer Registry of Norway, Oslo, Norway;

21. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;

22. Samfundet Folkhälsan, Helsinki, Finland;

23. Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain;

24. CIBER Epidemiology and Public Health CIBERESP, Spain;

25. Navarre Public Health Institute, Pamplona, Spain;

26. Translational Research Laboratory and Unit of Nutrition, Environment and Cancer Research Program in Cancer Epidemiology, Catalan Institute of Oncology, Biomedical Research Institute (IDIBELL), Barcelona, Spain;

27. Public Health Direction and Biodonostia Research Institute Ciberesp, Basque Regional Health Department, Vitoria, Spain;

28. Public Health Directorate, Asturias, Spain;

29. Andalusian School of Public Health, Granada, Spain;

30. Instituto de Investigación Biosanitario de Granada, Granada, Spain;

31. Department of Radiation Sciences, Oncology Umeå University, Umeå, Sweden;

32. Department of Laboratory Medicine, Clinical Chemistry, Lund University, Malmö, Sweden;

33. Skåne University Hospital, Malmö, Sweden;

34. Division of Oncology, Department of Clinical Sciences, Lund University, Malmö, Sweden;

35. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht;

36. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands;

37. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands;

38. The School of Public Health, Imperial College London, London, United Kingdom;

39. MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom;

40. School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom;

41. Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom;

42. Genetics Section, International Agency for Research on Cancer, Lyon, France;

43. Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom;

44. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; and

45. Human Genetics Foundation, Turin, Italy

Abstract

Key Points This study strengthens the previous observation of elevated mitochondrial DNA copy number and future risk of chronic lymphocytic leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference24 articles.

1. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress.;Lee;Int J Biochem Cell Biol,2005

2. Transcription of the mammalian mitochondrial genome.;Clayton;Annu Rev Biochem,1984

3. Normal oxidative damage to mitochondrial and nuclear DNA is extensive.;Richter;Proc Natl Acad Sci U S A,1988

4. Oxidative damage to DNA: formation, measurement, and biological significance.;Cadet;Rev Physiol Biochem Pharmacol,1997

5. Chemical determination of free radical-induced damage to DNA.;Dizdaroglu;Free Radic Biol Med,1991

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