Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo-Reference-Cited by-同舟云学术

Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo

Published:2014-09-11 Issue:11 Volume:124 Page:1737-1747
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yu Hui¹²,Neale Geoffrey³,Zhang Hui⁴,Lee Han M.⁴,Ma Zhijun¹,Zhou Sheng¹,Forget Bernard G.⁴,Sorrentino Brian P.¹

Affiliation:

1. Experimental Hematology Division, Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN;

2. Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, TN;

3. Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN; and

4. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT

Abstract

Key Points HOXB4 induces stable gene expression changes in transplanted HSCs that drive balanced self-renewal and differentiation divisions. Marked downregulation of Prdm16 occurs concurrently with HOXB4-mediated HSC expansion and functions to prevent leukemia in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/11/1737/1468523/1737.pdf

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