In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells

Author:

Rashidi Narges M.1,Scott Mark K.1,Scherf Nico2,Krinner Axel2,Kalchschmidt Jens S.1,Gounaris Kleoniki1,Selkirk Murray E.1,Roeder Ingo2,Lo Celso Cristina1

Affiliation:

1. Department of Life Sciences, Imperial College London, London, United Kingdom; and

2. Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Abstract

Key Points Normally, engrafting HSCs reside and oscillate within confined bone marrow niches. HSCs harvested from mice bearing acute infection are migratory and interact with larger niches.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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