Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm-Reference-Cited by-同舟云学术

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

Published:2014-08-14 Issue:7 Volume:124 Page:1136-1145
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lamrani Lamia¹²,Lacout Catherine³⁴⁵,Ollivier Véronique¹²,Denis Cécile V.⁴⁶,Gardiner Elizabeth⁷,Ho Tin Noe Benoit¹²,Vainchenker William³⁴⁵,Villeval Jean-Luc³⁴⁵,Jandrot-Perrus Martine¹²

Affiliation:

1. INSERM, U1148, Paris, France;

2. Université Paris Denis Diderot 7, Paris, France;

3. INSERM, U1009, Villejuif, France;

4. Université Paris-Sud 11, Villejuif, France;

5. Institut Gustave Roussy, Villejuif, France;

6. INSERM, U770, Le Kremlin-Bicêtre, France; and

7. Monash University, Clayton, VIC, Australia

Abstract

Key Points Mice constitutively developing a JAK2V617F-induced PV exhibit a bleeding tendency combined with the accelerated formation of unstable clots. Hemostatic defects are not concomitant with JAK2V617F expression, suggesting they are not directly caused by the mutation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/7/1136/1383840/1136.pdf

Reference51 articles.

1. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.;James;Nature,2005

2. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.;Baxter;Lancet,2005

3. A gain-of-function mutation of JAK2 in myeloproliferative disorders.;Kralovics;N Engl J Med,2005

4. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.;Levine;Cancer Cell,2005

5. Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia.;Elliott;Br J Haematol,2005

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