Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children-Reference-Cited by-同舟云学术

Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children

Published:2014-03-27 Issue:13 Volume:123 Page:2008-2016
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Atkinson Sarah H.¹²³,Uyoga Sophie M.³,Nyatichi Emily³,Macharia Alex W.³,Nyutu Gideon³,Ndila Carolyne³,Kwiatkowski Dominic P.⁴⁵,Rockett Kirk A.⁴⁵,Williams Thomas N.³⁶

Affiliation:

1. Department of Paediatrics, Oxford University Hospitals National Health Service Trust, University of Oxford, and

2. Oxford University Clinical Academic Graduate School, Oxford, United Kingdom;

3. Kenya Medical Research Institute/Wellcome Trust Research Programme, Centre of Geographic Medicine Research-Coast, Kilifi District Hospital, Kilifi, Kenya;

4. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;

5. Wellcome Trust Sanger Institute, Hinxton, United Kingdom; and

6. Department of Medicine, Imperial College, London, United Kingdom

Abstract

Key PointsEpistasis between the haptoglobin (Hp) common variants and α+thalassemia predicts the risk of severe malaria in Kenyan children. The inconsistent relationship between Hp type and malaria reported in previous studies may be explained by this epistatic interaction.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/13/2008/1374835/2008.pdf

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