Serological investigation of patients with a previous history of heparin-induced thrombocytopenia who are reexposed to heparin

Abstract

Key Points Heparin rechallenge despite prior HIT often induces platelet-activating anti-PF4/heparin antibodies but no faster than seen with typical HIT. Risk of HIT recurring after heparin rechallenge is low but possible if IgG with heparin-independent platelet-activating properties are made.